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Hydrocortisone-d7
$585
Only 1000 item(s) left in stock.
Products Details
Product Description
– Hydrocortisone-d7 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
Web ID
– HY-N0583S1
Shipping
– Room temperature
Molecular Formula
– C21H23D7O5
References
– [1]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 369.50
SMILES
– C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology; Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Glucocorticoid Receptor;Isotope-Labeled Compounds
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
