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Product Description
– Hydrochlorothiazide-13C6 is the 13C labeled Hydrochlorothiazide[1]. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[2][3][4].
Web ID
– HY-B0252S2
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C 13C6H8ClN3O4S2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802.|[3]Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 1720(1):3.|[4]Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr35(2).
CAS Number
– 1261396-79-5
Molecular Weight
– 303.70
SMILES
– O=S1([13C]2=[13CH][13C](S(N)(=O)=O)=[13C](Cl)[13CH]=[13C]2NCN1)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Potassium Channel;TGF-beta/Smad
Pathway
– Membrane Transporter/Ion Channel;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Isotope-Labeled Compounds
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