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Products Details
Product Description
– HX103 is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-based fluorogenic probe. HX103 inhibits EGFR 19 del, EGFR L858R, EGFR wild type and EGFR T790M with IC50s of 1.3, 1.5, 4.0 and 977 nM, respectively. HX103 can be used for quantifying active-EGFR to predict agent sensitivity in NSCLC patients with EGFR-activating mutations[1].
Web ID
– HY-152098
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H25ClFN7O5S
References
– [1]Deng H, et al. A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations. Nat Commun. 2022 Nov 14;13(1):6944.
CAS Number
– 2566466-98-4
Molecular Weight
– 602.04
SMILES
– COC1=C(C=C2N=CN=C(C2=C1)NC3=CC(Cl)=C(C=C3)F)OCCCNC4=CC=C(C5=NON=C45)S(=O)(N(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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