Download Files:
HWL-088
$350 – $2,500
Products Details
Product Description
– HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects[1][2].
Web ID
– HY-130120
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C22H19FO4
References
– [1]Li Z, et al. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold. Bioorg Chem. 2019 Nov;92:103209.|[2]Yueming Chen, et al. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. Br J Pharmacol. 2020 May;177(10):2286-2302.
CAS Number
– 2378617-96-8
Molecular Weight
– 366.38
Compound Purity
– 98.80
SMILES
– CC1=CC=CC=C1C2=CC(COC3=CC=C(OCC(O)=O)C(F)=C3)=CC=C2
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Free Fatty Acid Receptor;PPAR
Isoform
– PPARβ/δ
Pathway
– Cell Cycle/DNA Damage;GPCR/G Protein;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
