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Products Details
Product Description
– HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb[1].
Web ID
– HY-157084
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C78H97N9O18S
References
– [1]Carlson DL, et al. Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development. Cell Chem Biol. 2023 Nov 1:S2451-9456(23)00340-9.
Molecular Weight
– 1480.72
SMILES
– O=C(CCC1=C(N2)/C=C3C(CCC(OC)=O)=C(C)C(/C=C4N/C(C(C)=C4C=C)=CC(C5=CC=C([C@H]([C@]5/6C)C(OC)=O)C(OC)=O)=NC6=C/C2=C1C)=N/3)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC7=CC=C(N8C(NN=C8C9=C(O)C=C(O)C(C(C)C)=C9)=S)C=C7)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;ROS Kinase
Pathway
– Anti-infection;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
