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Products Details
Product Description
– HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity[1].
Web ID
– HY-149773S
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H20D2FN7O3
References
– [1] Jing Ai, et al. Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors. Journal of Medicinal Chemistry. 2023，Article ASAP.
Molecular Weight
– 477.49
SMILES
– OC([2H])([C@@H](NC1=NC(NC2=CC(C(C)(N3)C)=C(C=C2)C3=O)=NC=C1C4=NN=CO4)C5=CC=C(C=C5)F)[2H]
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– MAP4K
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
