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Products Details
Product Description
– HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch[1].
Web ID
– HY-152257
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C30H33N7O3
References
– [1]Ming-Shu Wang, et al. Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy. J Med Chem. 2023 Jan 12;66(1):611-626.Â
Molecular Weight
– 539.63
SMILES
– CC(O)(CN1C=C(C=N1)C2=CN=C3N=C2N[C@@H](C4=C(OCCCCC5=CC(N3)=CC=C5C#N)C=CC=C4)CO)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– MAP4K
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
