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Products Details
Product Description
– HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body’s anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1)[1].
Web ID
– HY-143869
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H22F3N5O4
References
– [1]Jiang Lei, et al. Novel hpk1 inhibitors and methods of preparation and application thereof. Patent WO2021175270A1.
CAS Number
– 2699603-89-7
Molecular Weight
– 513.47
SMILES
– FC1=C(OC2=NC=NC3=C2C(C4=C(F)C=C(OC)C=C4)=CN3)C(F)=CC(NC5=NCC(CO)(CO5)C)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MAP4K
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
