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Products Details
Product Description
– HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].
Web ID
– HY-145690
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H23N3O3
References
– [1]Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65(4):3597-3605.
CAS Number
– 2245074-20-6
Molecular Weight
– 389.45
SMILES
– OCCOC1=CC=C(CNC2=CC(N=CN3C4=CC=CC=C4)=C3C=C2)C=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FLT3
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
