Download Files:
Products Details
Product Description
– hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (Ki: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson’s disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent[1].
Web ID
– HY-149941
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C37H62N10O9
References
– [1]Kühl T, et al. Neurotensin(8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson’s disease. Eur J Med Chem. 2023 Jun 5;254:115386.
Molecular Weight
– 790.95
SMILES
– O=C([C@H]1N(CCC1)C([C@H](CCONC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](CC)C)=O)CC2=CC=C(O)C=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Neurotensin Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
