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Products Details
Product Description
– hnNOS-IN-3 (compound 39) is a selective nNOS inhibitor, with a Ki of 0.32 μM. The nNOS binding of hnNOS-IN-3 is competitive with L-arginine. The selectivity of hnNOS-IN-3 for nNOS versus iNOS (Ki=37 μM) and eNOS (Ki=9.4 μM) is 115-fold and 29-fold, respectively[1].
Web ID
– HY-W484263
Shipping
– Room temperature
Molecular Formula
– C10H12ClF3N2S
References
– [1]Shearer BG, et al. Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem. 1997 Jun 6;40(12):1901-5.
CAS Number
– 163490-78-6
Molecular Weight
– 284.73
SMILES
– N=C(SCC)NC1=CC=C(C(F)(F)F)C=C1.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– NO Synthase
Isoform
– eNOS;iNOS;nNOS
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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