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Products Details
Product Description
– HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity[1].
Web ID
– HY-12352
Shipping
– Room temperature
Molecular Formula
– C18H17ClN2O4S
References
– [1]Chen H, et al. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2014 Jul 23;82:195-203.
CAS Number
– 1617518-22-5
Molecular Weight
– 392.86
SMILES
– O=C(NC1=CC=C(C=CS2(=O)=O)C2=C1)C3=CC(Cl)=CC=C3OCCCN
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;STAT
Isoform
– STAT3
Pathway
– Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
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