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HIV-1 inhibitor-8
$300 – $2,400
Products Details
Product Description
– HIV-1 inhibitor-8 is an orally active, low-toxicity and potent HIV‑1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC50=4.44~54.5 nM) against various HIV‑1 strains. The IC50 of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM[1].
Web ID
– HY-132291
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C25H21N5OS
References
– [1]Wang Z, et al. Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles [published online ahead of print, 2021 Aug 25]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01015.
CAS Number
– 2826996-78-3
Molecular Weight
– 439.53
Compound Purity
– 98.03
SMILES
– N#CC1=CC=C(NC2=NC(OC3=C(C)C=C(/C=C/C#N)C=C3C)=C(CSCC4)C4=N2)C=C1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– HIV
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
