Download Files:
HIF-2α-IN-8
$300 – $1,400
Products Details
Product Description
– HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
Web ID
– HY-148860
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H11ClF7N3O
References
– [1]Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1.
CAS Number
– 2734922-78-0
Molecular Weight
– 441.73
Compound Purity
– 99.85
SMILES
– FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– HIF/HIF Prolyl-Hydroxylase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
