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Products Details
Product Description
– hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Web ID
– HY-144130
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H19BrN4O7P2S
References
– [1]Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65(3):2471-2496.
CAS Number
– 2763223-96-5
Molecular Weight
– 613.31
SMILES
– O=C(C1=CC(C2=NC3=C(C(NC(P(O)(O)=O)P(O)(O)=O)=N2)C=CS3)=CC=C1)NC4=CC(Br)=C(C=C4)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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