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Products Details
Product Description
– hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Web ID
– HY-144128
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H13N3O6P2S
References
– [1]Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65(3):2471-2496.
CAS Number
– 1429012-38-3
Molecular Weight
– 401.27
SMILES
– O=P(O)(C(P(O)(O)=O)NC1=C2C=CSC2=NC(C3=CC=CC=C3)=N1)O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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