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Product Description
– Hesperetin-d3 is the deuterium labeled Hesperetin[1]. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis[2][3].
Web ID
– HY-N0168S
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H11D3O6
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.|[3]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301.
Molecular Weight
– 305.30
SMILES
– O=C1C[C@@H](C2=CC=C(OC([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C13
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;p38 MAPK
Pathway
– Apoptosis;Autophagy;MAPK/ERK Pathway
Product type
– Isotope-Labeled Compounds
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