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Products Details
Product Description
– hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].
Web ID
– HY-135654
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C19H16N2O2
References
– [1]Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.|[2]Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.
CAS Number
– 183946-00-1
Molecular Weight
– 304.34
SMILES
– O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=C(C3CC3)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Dihydroorotate Dehydrogenase;DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
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