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Products Details
Product Description
– hDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer[1].
Web ID
– HY-151381
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H15ClF4N2O4
References
– [1]Chungen Li, et al. Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold. European Journal of Medicinal Chemistry, 2022, 243 (5), 114737.
Molecular Weight
– 470.80
SMILES
– C/C(O)=C(C(NC1=C(C=C(C(O[C@H](C(F)(F)F)C)=C1)C(C2=C(C=CC=C2)Cl)=O)F)=O)C#N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Dihydroorotate Dehydrogenase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
