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Products Details
Product Description
– A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.
Web ID
– HY-147730
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H17BrFN5O3
References
– [1]Li X,et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 May 24;125:105874.
CAS Number
– 2796282-49-8
Molecular Weight
– 510.32
SMILES
– O=C(NC1=CC=C2N=CN=C(C2=C1)NC3=CC(F)=C(C=C3)Br)CC4=CC=C(C=C4)C(NO)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
