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Products Details
Product Description
– HDAC6-IN-22 (compound 30) is a inhibitor of HDAC6, with the IC50 of 4.63 nM. HDAC6-IN-22 has antiproliferative effects in vitro and in vivo towards multiple myeloma. HDAC6-IN-22
induces cell cycle arrest in the G2 phase and promotes apoptosis through the mitochondrial pathway[1].
Web ID
– HY-156279
Shipping
– Room temperature
Molecular Formula
– C24H24N4O2
References
– [1]Liu L, et al. Design and synthesis of 1H-benzo[d]imidazole selective HDAC6 inhibitors with potential therapy for multiple myeloma [published online ahead of print, 2023 Sep 25]. Eur J Med Chem. 2023;261:115833.
Molecular Weight
– 400.47
SMILES
– CN1C2=CC=C(C(NO)=O)C=C2N=C1[C@H](CC3=CC=CC=C3)NCC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
