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Products Details
Product Description
– HDAC6-IN-18 (Compound 4) is a first irreversible HDAC6 isoform selective inhibitor with potent anti-multiple myeloma activity. HDAC6-IN-18 has HDAC6 inhibitory activity in RPMI8266, U266 and MM.1S cells with IC50 values of 0.17, 0.7 and 0.42 μM, respectively[1].
Web ID
– HY-155671
Shipping
– Room temperature
Molecular Formula
– C16H13N3O7S
References
– [1]Liu F, et al. Discovery of the First Irreversible HDAC6 Isoform Selective Inhibitor with Potent Anti-Multiple Myeloma Activity. J Med Chem. 2023 Jul 27;66(14):10080-10091.
Molecular Weight
– 391.36
SMILES
– [O-][N+]1=C(C(OCC2=CC=C(C=C2)C(NO)=O)=NO1)S(=O)(C3=CC=CC=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
