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HDAC6-IN-10
SKU
HY-150595-Get quote
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics, HDAC;Microtubule/Tubulin
Products Details
Product Description
– HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1].
Web ID
– HY-150595
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H20N4O4
References
– [1]Xin Chen, et al. Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. Eur J Med Chem. 2020 Feb 1;187:111950.
CAS Number
– 2408286-73-5
Molecular Weight
– 392.41
SMILES
– O=C(NO)C1=CC=C(CN2C([C@@H](CC3=CNC4=C3C=CC=C4)NC(C2)=O)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;Microtubule/Tubulin
Isoform
– HDAC1;HDAC10;HDAC11;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.