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Products Details
Product Description
– HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1].
Web ID
– HY-150595
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H20N4O4
References
– [1]Xin Chen, et al. Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. Eur J Med Chem. 2020 Feb 1;187:111950.
CAS Number
– 2408286-73-5
Molecular Weight
– 392.41
SMILES
– O=C(NO)C1=CC=C(CN2C([C@@H](CC3=CNC4=C3C=CC=C4)NC(C2)=O)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;Microtubule/Tubulin
Isoform
– HDAC1;HDAC10;HDAC11;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
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