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HDAC3/6-IN-2
SKU
HY-133147-Get quote
Category Reference compound
Tags Apoptosis;Cell Cycle/DNA Damage;Epigenetics, Apoptosis;HDAC, Cancer
Products Details
Product Description
– HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].
Web ID
– HY-133147
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C49H67N5O6
References
– [1]Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.
CAS Number
– 2417510-17-7
Molecular Weight
– 822.09
SMILES
– O=C(NC1=CC=C(N2CCN(C([C@](CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C57)=O)(C)C[C@@]3([H])C4=CC7=O)=O)CC2)C=C1)CCCCCCC(NO)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC
Isoform
– HDAC1;HDAC2;HDAC3;HDAC6
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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