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Products Details
Product Description
– HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites[1].
Web ID
– HY-144297
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C22H24ClN7O2
References
– [1]Wang M, et al. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022; 65(5):4156-4181.
CAS Number
– 2482998-35-4
Molecular Weight
– 453.92
SMILES
– O=C(C1=CN=C(N(CC2)CC32CN(CC4=CN(C)C5=C4C=CC(C#N)=C5)C3)N=C1)NO.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HDAC;Parasite
Isoform
– HDAC1;HDAC2;HDAC3;HDAC6;HDAC8;Plasmodium
Pathway
– Anti-infection;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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