Download Files:
Products Details
Product Description
– HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites[1].
Web ID
– HY-144297
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C22H24ClN7O2
References
– [1]Wang M, et al. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022; 65(5):4156-4181.
CAS Number
– 2482998-35-4
Molecular Weight
– 453.92
SMILES
– O=C(C1=CN=C(N(CC2)CC32CN(CC4=CN(C)C5=C4C=CC(C#N)=C5)C3)N=C1)NO.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HDAC;Parasite
Isoform
– HDAC1;HDAC2;HDAC3;HDAC6;HDAC8;Plasmodium
Pathway
– Anti-infection;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
