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HDAC1/6-IN-1

Products Details

Product Description

– HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].

Web ID

– HY-144725

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C32H45N7O4

References

– [1]Zheng H, et al. Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents. Bioorg Med Chem. 2022 Jan 1;53:116524.

CAS Number

– 2630989-02-3

Molecular Weight

– 591.74

SMILES

– COC1=C(C=C2C(N=C(N=C2NC3CCN(CC3)CC4=CC=CC=C4)N5CCN(CC5)CCCCCC(NO)=O)=C1)OC

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Apoptosis;HDAC

Isoform

– HDAC1;HDAC6

Pathway

– Apoptosis;Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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