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Products Details
Product Description
– HDAC-IN-57 is an orally active inhibitor of histone deacetylases (HDAC), with IC50s of 2.07 nM, 4.71 nM, 2.4 nM and 107 nM for HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-57 can inhibits LSD1, with IC50 of 1.34 μΜ. HDAC-IN-57 induces apoptosis, and has anti-tumor activity[1].
Web ID
– HY-149946
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H19N3O4
References
– [1]Duan Y, et al. Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors. Eur J Med Chem. 2023 Jun 5;254:115367.
CAS Number
– 2716217-79-5
Molecular Weight
– 377.39
SMILES
– O=C(C1=CC=C(CNC(C2=CC(C3=CC=C(OC)C=C3)=NC=C2)=O)C=C1)NO
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC;Histone Demethylase
Isoform
– HDAC1;HDAC2;HDAC6;HDAC8
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
