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Products Details
Product Description
– HDAC-IN-57 is an orally active inhibitor of histone deacetylases (HDAC), with IC50s of 2.07 nM, 4.71 nM, 2.4 nM and 107 nM for HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-57 can inhibits LSD1, with IC50 of 1.34 μΜ. HDAC-IN-57 induces apoptosis, and has anti-tumor activity[1].
Web ID
– HY-149946
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H19N3O4
References
– [1]Duan Y, et al. Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors. Eur J Med Chem. 2023 Jun 5;254:115367.
CAS Number
– 2716217-79-5
Molecular Weight
– 377.39
SMILES
– O=C(C1=CC=C(CNC(C2=CC(C3=CC=C(OC)C=C3)=NC=C2)=O)C=C1)NO
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC;Histone Demethylase
Isoform
– HDAC1;HDAC2;HDAC6;HDAC8
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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