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Products Details
Product Description
– HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer[1].
Web ID
– HY-152173
Shipping
– Room temperature
Molecular Formula
– C27H24N4O2
References
– [1]Di Bello E, et, al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022.
Molecular Weight
– 436.51
SMILES
– NC1=CC=CC=C1NC(C2=NC=C(C=C2)NC(C(C3=CC=CC=C3)CC4=CC=CC=C4)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;CDK;HDAC
Isoform
– HDAC1;HDAC10;HDAC11;HDAC2;HDAC3
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
