Download Files:

HDAC-IN-37

Products Details

Product Description

– HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis[1].

Web ID

– HY-146750

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C23H24ClN7O

References

– [1]Mao PT, He WB, Mai X, et al. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors. Bioorg Med Chem.

CAS Number

– 2766466-56-0

Molecular Weight

– 449.94

SMILES

– CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Apoptosis;HDAC

Isoform

– HDAC1;HDAC3;HDAC6;HDAC8

Pathway

– Apoptosis;Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

My Cart
Close Wishlist
Close Recently Viewed
Categories

Please fill out this form to request the file. We will send it to your Email address shortly. Thanks.

Please enable JavaScript in your browser to complete this form.

=

Please fill out this form to request the pricing.
We will send it to your email address shortly.
Thanks.

Please enable JavaScript in your browser to complete this form.

=