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Products Details
Product Description
– HDAC/BET-IN-1 displays submicromolar inhibitory activity against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM), and BRD4 (Ki = 0.076 μM), and possess potent antileukemia activity.
Web ID
– HY-141844
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H40N4O8S
References
– [1]Schäker-Hübner L, et al. 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J Med Chem. 2021 Oct 14;64(19):14620-14646.
CAS Number
– 2757573-68-3
Molecular Weight
– 604.71
SMILES
– CC1=C2C(CCCCC2=C(N1)C(NC3=CC(S(N4CCOCC4)(=O)=O)=CC=C3OCCCCCCCC(NO)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
