Download Files:
Products Details
Product Description
– hCYP1B1-IN-1 (compound B18) is a hCYP1B1 inhibitor (IC50=3.6 nM)，as well as an antagonist of Aryl Hydrocarbon Receptor. hCYP1B1-IN-1 exhibtis suitable metabolic stability and good cell-permeability. hCYP1B1-IN-1 inhibits migration of MCF-7 cells[1].
Web ID
– HY-155061
Shipping
– Room temperature
Molecular Formula
– C18H14ClF3O3
References
– [1]Wu Y, et al. Discovery of 4′-trifluoromethylchalcones as novel, potent and selective hCYP1B1 inhibitors without concomitant AhR activation. Eur J Med Chem. 2023 Oct 5;258:115552.
Molecular Weight
– 370.75
SMILES
– FC(F)(F)C1=CC=C(C(/C=C/C2=C(OC)C=C(OC)C(Cl)=C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aryl Hydrocarbon Receptor;Cytochrome P450
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
