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Products Details
Product Description
– hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II[1].
Web ID
– HY-147829
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H18ClN3O4
References
– [1]Pavitra S Thacker, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.
CAS Number
– 2497504-86-4
Molecular Weight
– 411.84
SMILES
– O=C1C=C(CCl)C2=CC=C(OCC3=CN(CC4=CC=C(OC)C=C4)N=N3)C=C2O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA â…¨;CA XII
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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