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Products Details
Product Description
– hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II[1].
Web ID
– HY-147829
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H18ClN3O4
References
– [1]Pavitra S Thacker, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.
CAS Number
– 2497504-86-4
Molecular Weight
– 411.84
SMILES
– O=C1C=C(CCl)C2=CC=C(OCC3=CN(CC4=CC=C(OC)C=C4)N=N3)C=C2O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA â…¨;CA XII
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
