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Products Details
Product Description
– hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1].
Web ID
– HY-146988
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H11NO5S2
References
– [1]Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541.
Molecular Weight
– 397.42
SMILES
– O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=CC4=CC=CS4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Carbonic Anhydrase
Isoform
– CA Ⅸ
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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