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Products Details
Product Description
– hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 µM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) [1].
Web ID
– HY-146254
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H14N4O3S2
References
– [1]Shamsi F, et al. Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy. Bioorg Chem. 2020 May;98:103754.
CAS Number
– 2414598-85-7
Molecular Weight
– 398.46
SMILES
– O=S(C1=CC=C(N)C=C1)(NC2=C(C3=NC(C4=CC=CC=C4)=NO3)SC=C2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Carbonic Anhydrase;Reactive Oxygen Species
Isoform
– CA Ⅸ
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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