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Products Details
Product Description
– Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively[1].
Web ID
– HY-146587
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C12H8N4O3
References
– [1]Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369.
CAS Number
– 2768474-47-9
Molecular Weight
– 256.22
SMILES
– COC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK;DYRK;Haspin Kinase
Isoform
– CLK;DYRK1
Pathway
– Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
