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Products Details
Product Description
– Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively[1].
Web ID
– HY-146586
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C12H8N4O2S
References
– [1]Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369.
CAS Number
– 2768474-30-0
Molecular Weight
– 272.28
SMILES
– CSC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK;DYRK;Haspin Kinase
Isoform
– CLK;DYRK1
Pathway
– Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
