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Products Details
Product Description
– Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].
Web ID
– HY-122950
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H27NO6
References
– [1]Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. |[2]De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445.
CAS Number
– 157148-06-6
Molecular Weight
– 365.42
SMILES
– CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)C=CC=CCCC)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Fungal
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
