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Products Details
Product Description
– Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum[1]. Halofantrine blocks HERG potassium channels[2].
Web ID
– HY-A0148
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H30Cl2F3NO
References
– [1]A J Humberstone, et al. Effect of altered serum lipid concentrations on the IC50 of halofantrine against <i>Plasmodium falciparum</i>. J Pharm Sci. 1998 Feb;87(2):256-8.|[2]H Tie, et al. Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br J Pharmacol. 2000 Aug;130(8):1967-75.|[3]Ji-Hyun Lee, et al. CDA: combinatorial drug discovery using transcriptional response modules. PLoS One. 2012;7(8):e42573.|[4]Joël Lelièvre, et al. Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence “transmission blocking” assay. PLoS One. 2012;7(4):e35019.
CAS Number
– 69756-53-2
Molecular Weight
– 500.42
SMILES
– OC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31
Clinical Information
– Launched
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite;Potassium Channel
Isoform
– Plasmodium
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Reference compound
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