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Products Details
Product Description
– hAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer’s disease (AD) research[1].
Web ID
– HY-155366
Shipping
– Room temperature
Molecular Formula
– C20H17BrN4O2
References
– [1]Omnia M Waly, et al. Multi-targeted anti-Alzheimer’s agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids. Eur J Med Chem. 2023 Oct 20:262:115880.
Molecular Weight
– 425.28
SMILES
– NC1=NNC2=NC(C3=CC=C(Br)C=C3)=CC(C4=CC(OC)=C(OC)C=C4)=C21
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE);GSK-3
Isoform
– AChE;BChE;GSK-3β
Pathway
– Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
