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GW311616 (hydrochloride)
$450
Only 1000 item(s) left in stock.
Products Details
Product Description
– GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM[1].
Web ID
– HY-15891A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H32ClN3O4S
Citations
– Int Immunopharmacol. 2022 Dec 7;114:109537.|J Invest Dermatol. 2020 Jul;140(7):1371-1378.e3.|Adv Sci (Weinh). 2023 Jun 22;e2302613.|Cell Immunol. 2020 Jun;352:104101.|EMBO Rep. 2023 Aug 31;e57032.|J Leukoc Biol. 2022 Aug 19.|Life Sci. 2020 Feb 1;242:117229.|Sci Rep. 2017 Nov 30;7(1):16628.
References
– [1]Ohbayashi H,et al. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.|[2]Jiang KL, et al. Neutrophil elastase and its therapeutic effect on leukemia cells. Mol Med Rep. 2015 Sep;12(3):4165-4172.|[3]Macdonald SJ, et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase–GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.
CAS Number
– 197890-44-1
Molecular Weight
– 433.99
Compound Purity
– 98.84
SMILES
– O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– H2O : 100 mg/mL (ultrasonic)|DMSO : 100 mg/mL (ultrasonic)
Target
– Elastase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
