Download Files:
GW 441756
$65 – $435
Products Details
Product Description
– GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3].
Web ID
– HY-18314
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H13N3O
References
– [1]Zhao F, et al. BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth via NGF/TrkA Signaling Pathway. Toxins (Basel). 2021;13(1):33. Published 2021 Jan 5.|[2]Terada K, et al. Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. PLoS One. 2018;13(12):e0209250. Published 2018 Dec 17.|[3]Wood ER, et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004;14(4):953-957.
CAS Number
– 504433-23-2
Molecular Weight
– 275.30
Compound Purity
– 99.95
SMILES
– O=C1/C(C2=NC=CC=C2N1)=CC3=CN(C)C4=C3C=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 17.5 mg/mL (ultrasonic;warming)
Target
– Apoptosis;Trk Receptor
Isoform
– TrkA
Pathway
– Apoptosis;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
