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Product Description
– Guanosine 5′-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5′-triphosphate-sensitive K+ channel. Guanosine 5′-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5′-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI)[1][2].
Web ID
– HY-113066C
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C10H14N5NaO11P2
References
– [1]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5′-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. |[2]Angmo S, et al. Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.
CAS Number
– 43139-22-6
Molecular Weight
– 465.18
SMILES
– O=P(OP([O-])(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1.[Na+]
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Potassium Channel
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Biochemical Assay Reagents
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
