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Guadecitabine sodium
$850 – $1,200
Products Details
Product Description
– Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)[1].
Web ID
– HY-15229
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H23N9NaO10P
Citations
– Research Square Print. January 3rd, 2023.|Cancer Res. 2020 Jul 15;80(14):3046-3056.|Epigenomes. 2021, 5(4), 27.|J Exp Clin Cancer Res. 2023 Mar 18;42(1):67.|Mol Cell. 2022 Sep 29;S1097-2765(22)00896-6.|Neoplasia. 2020 May 25;22(7):274-282.|University of Siena. Department of Medical Biotechnologies. 2021 May.
References
– [1]Yoo CB, et al. Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67(13):6400-8.|[2]Chuang JC, et al. S-110, a 5-Aza-2′-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9(5):1443-50.
CAS Number
– 929904-85-8
Molecular Weight
– 579.39
Compound Purity
– 98.05
SMILES
– O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](COP(O[C@@H]4[C@@H](CO)O[C@@H](N5C=NC(N)=NC5=O)C4)(O[Na])=O)O3)C=N2)NC(N)=N1
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– H2O : 50 mg/mL (ultrasonic;warming)|DMSO : 50 mg/mL (ultrasonic)
Target
– DNA Methyltransferase
Isoform
– DNMT1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
