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Products Details
Product Description
– Guadecitabine (SGI-110) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)[1].
Web ID
– HY-13542
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H24N9O10P
Citations
– Cancer Res. 2020 Jul 15;80(14):3046-3056.|Epigenomes. 2021, 5(4), 27.|J Exp Clin Cancer Res. 2023 Mar 18;42(1):67.|Mol Cell. 2022 Sep 29;S1097-2765(22)00896-6.|Neoplasia. 2020 May 25;22(7):274-282.|University of Siena. Department of Medical Biotechnologies. 2021 May.|Research Square Print. January 3rd, 2023.
References
– [1]Chuang JC, et al. S110, a 5-Aza-2′-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9(5):1443-50.|[2]Foulks JM, et al. Epigenetic drug discovery: targeting DNA methyltransferases.
J Biomol Screen. 2012 Jan;17(1):2-17.|[3]Coral S, et al. Immunomodulatory activity of SGI-110, a 5-aza-2′-deoxycytidine-containing demethylating dinucleotide.
Cancer Immunol Immunother. 2013 Mar;62(3):605-14.
CAS Number
– 929901-49-5
Molecular Weight
– 557.41
Compound Purity
– 98.0
SMILES
– O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](COP(O)(O[C@@H]4[C@@H](CO)O[C@@H](N5C=NC(N)=NC5=O)C4)=O)O3)C=N2)NC(N)=N1
Clinical Information
– Phase 3
Research Area
– Cancer
Target
– DNA Methyltransferase
Isoform
– DNA Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
