GSK583

SKU HY-100339-10 mg Category Tags , ,

$84$1,440

$264
Only 1000 item(s) left in stock.

Products Details

Product Description

– GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.

Web ID

– HY-100339

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C20H19FN4O2S

References

– [1]Haile PA et al. The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem, 2016 May 26, 59(10):4867-80.

CAS Number

– 1346547-00-9

Molecular Weight

– 398.45

Compound Purity

– 98.74

SMILES

– FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1

Clinical Information

– No Development Reported

Research Area

– Endocrinology

Solubility

– DMSO : ≥ 100 mg/mL

Target

– RIP kinase

Pathway

– Apoptosis

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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