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Products Details
Product Description
– GSK466317A is a PKA inhibitor, with an IC50 of 12.59 μM. GSK466317A also inhibits GRK1, GRK2, and GRK5, with IC50s of 1000, 31.62, and 39.81 μM, respectively[1].
Web ID
– HY-119232
Shipping
– Room temperature
Molecular Formula
– C21H16ClF3N4O2
References
– [1]Homan KT, et, al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9.
CAS Number
– 864082-48-4
Molecular Weight
– 448.83
SMILES
– O=C(NC1=CC2=C(C(Cl)=C1)NN=C2)C3=C(NC(CC3C4=CC=C(C=C4)C(F)(F)F)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– G Protein-coupled Receptor Kinase (GRK);PKA
Isoform
– PKA
Pathway
– GPCR/G Protein;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
