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GSK319347A
$190 – $1,965
Products Details
Product Description
– GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.
Web ID
– HY-14682
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H19N3O5S2
References
– [1]Johannes JW, et al. Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1138-43.|[2]Xie HZ, et al. Pharmacophore modeling and hybrid virtual screening for the discovery of novel IκB kinase 2 (IKK2) inhibitors. J Biomol Struct Dyn. 2011 Aug;29(1):165-79.
CAS Number
– 862812-98-4
Molecular Weight
– 469.53
Compound Purity
– 99.40
SMILES
– COC1=CC2=C(C=C1OC)N(C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)C=N2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 45 mg/mL (ultrasonic)
Target
– IKK
Isoform
– IKK-β;IKKε;TBK1
Pathway
– NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
