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GSK2647544
$450 – $3,400
Products Details
Product Description
– GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1].
Web ID
– HY-145653
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H18ClF3N4O3
References
– [1]Wu K, et al. Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers
. Int J Clin Pharmacol Ther. 2016;54(12):935-949.
CAS Number
– 1380426-95-8
Molecular Weight
– 502.87
Compound Purity
– 99.46
SMILES
– O=C1NC(OCCC2=CC=C(C=C2)OC3=CC=C(C(C(F)(F)F)=C3)Cl)=NC=C1CC4=CN=CN=C4
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Phospholipase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
