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Products Details
Product Description
– GR203040 is an orally active NK1 receptor antagonist with a pKi of 10.3. GR203040 shows potent antiemetic activity[1].
Web ID
– HY-10051
Shipping
– Room temperature
Molecular Formula
– C20H26Cl2N6O
References
– [1]Ward P, et al. Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity. J Med Chem. 1995 Dec 22;38(26):4985-92.
CAS Number
– 168398-02-5
Molecular Weight
– 437.37
SMILES
– COC1=CC=C(N2N=NN=C2)C=C1CN[C@@H]3[C@H](C4=CC=CC=C4)NCCC3.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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