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GNE-149
SKU
HY-145341-1 mg
Category Reference compound
Tags Cancer, Estrogen Receptor/ERR, Vitamin D Related/Nuclear Receptor
$220 – $5,800
Products Details
Product Description
– GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC50=0.053 nM). GNE-149 is a selective estrogen receptor degrader (SERD). GNE-149 can be used for the research of breast cancer[1].
Web ID
– HY-145341
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H33F4N3O
References
– [1]Jun Liang, et al. Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. ACS Med Chem Lett. 2020 May 26;11(6):1342-1347.
CAS Number
– 1953132-75-6
Molecular Weight
– 503.57
Compound Purity
– 99.66
SMILES
– CC(C)(F)CN1[C@@](C2=C(C=C(C=C2F)OC3CN(C3)CCCF)F)([H])C4=C(C[C@H]1C)C5=CC=CC=C5N4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Estrogen Receptor/ERR
Isoform
– ERα
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.